Peptide & Purification

Industrial Peptide Synthesiser

Mechotech designs and manufactures industrial peptide synthesisers for production-scale solid-phase peptide synthesis (SPPS). Mechotech lists peptide synthesisers in laboratory and industrial versions; this page covers the industrial version, built around an agitated reaction vessel in which the resin-bound peptide is assembled through automated coupling, deprotection and wash cycles. Vessel volume, materials of construction, hazardous-area construction and automation level are configured to the customer’s peptide, batch size and facility. The synthesiser sits at the front of Mechotech’s peptide synthesis and purification line, ahead of preparative HPLC, concentration, lyophilisation and solvent recovery.

A Mechotech industrial peptide synthesiser is configured around an agitated reaction vessel served by metered liquid dispensing, so that each coupling, deprotection and wash addition is delivered in sequence under recipe control. Options that are specified per project include jacketed temperature control, inert-gas (nitrogen) pressure transfer of reagents, online flow metering on solvent and reagent lines, a clean-in-place (CIP) system, an optional cleavage module and EX-proof or standard construction, with local and remote control. The SPPS chemistry strategy (Fmoc or t-Boc), the reactor volume and the control and documentation scope are confirmed with the client during project definition.

Technical Specifications

Product	Industrial Peptide Synthesiser
Technology	Industrial solid-phase peptide synthesis (SPPS)
Synthesis Strategy	Fmoc or t-Boc SPPS chemistry, selected for the peptide and confirmed with the client
Reaction Vessel	Agitated reaction vessel; volume configured to batch size and product
Temperature Control	Jacketed heating / cooling, where specified
Reagent Feed	Metered liquid dispensing; inert-gas (nitrogen) pressure transfer where specified
Flow Measurement	Online flow metering on solvent / reagent lines, where specified
Cleaning	Clean-in-place (CIP) system, where specified
Cleavage Unit	Optional module
Hazardous-Area Construction	EX-proof or standard construction; rating and certification specified and confirmed per project and facility classification
Control	Local and remote control; audit-trail / electronic-record scope confirmed with the client
Product-contact Material	Stainless steel 316L or chemically resistant lining, per product and solvent system
Plant Capacity	Configured to requirement
Compliance	GMP hygienic design; full documentation for qualification
Output	Resin-bound crude peptide; crude peptide after the optional cleavage module, for downstream purification

Plant Capacities

Plant Scale	Reactor Volume	Typical Use
Pilot	Configured to your peptide and trial plan	Process development, parameter validation
Semi-Commercial	Configured between pilot and commercial scale	Scale-up trials, contract manufacturing
Commercial	Configured to confirmed batch size and product volume	Production-scale peptide manufacturing

Reactor volume is configured to the peptide, batch size and facility. The metering, flow measurement, CIP, temperature control, hazardous-area construction and optional cleavage unit are scaled to the confirmed reactor.

Manufacturing Process

Resin Charging & Swelling

Resin is loaded into the reaction vessel and swelled in solvent under agitation, forming the support on which the peptide chain is assembled.

Reagent Transfer

Amino-acid, activator, deprotection and wash solutions are transferred to the vessel through metered lines, by inert-gas pressure where specified, with online flow metering where fitted.

Coupling

The activated amino acid is dosed into the vessel and mixed under temperature control where specified, forming the amide bond to the resin-bound chain.

Solvent Washing

Programmed solvent washes flush excess reagents and by-products from the resin bed between steps.

Deprotection

The temporary N-terminal protecting group is removed under controlled time and temperature so the amine is ready for the next coupling cycle.

Cycle Repetition

Coupling, washing and deprotection repeat for every residue in the sequence under recipe control, with step data recorded by the control system.

Clean-in-Place

Where a CIP system is specified, it cleans the vessel and internals between batches to help prevent carry-over; cleaning-validation requirements are defined with the client.

Cleavage (Optional Module)

The optional cleavage module releases the peptide from the resin and removes side-chain protection, delivering crude peptide for downstream purification.

Major Plant Equipment

Agitated reaction vessel (jacketed where specified)
Metered liquid dispensing system
Inert-gas (nitrogen) pressure-transfer system, where specified
Online flow meters on solvent and reagent lines, where specified
Reagent, solvent and wash vessels
Clean-in-place (CIP) system, where specified
Optional cleavage module
Local and remote control system

Plant Output

Resin-bound crude peptideCrude peptide after the optional cleavage module, for downstream purification

Applications

Peptide active pharmaceutical ingredient (API) manufacturing
Clinical-batch and production-scale peptide manufacturing
Contract development and manufacturing (CDMO) of peptides
Scale-up of validated research sequences

Key Features

Configurable Reactor Volume
The reaction vessel is sized to the peptide, batch size and facility rather than to a fixed catalogue volume.
Metered Reagent Delivery
Metered liquid dispensing, with inert-gas pressure transfer and online flow metering where specified, delivers each addition in sequence under recipe control.
Temperature-Controlled Steps
A jacketed vessel, where specified, holds coupling and deprotection steps at their set temperature.
Clean-in-Place Option
A CIP system, where specified, cleans the vessel and internals between batches to help prevent carry-over.
EX-Proof or Standard Construction
Hazardous-area (EX-proof) or standard construction is specified per project and facility classification, with local and remote control.
Optional Cleavage Module
An optional module releases the peptide from the resin and removes side-chain protection, so crude peptide can pass to purification.

Frequently Asked Questions

What is an industrial peptide synthesiser?

It is a production-scale solid-phase peptide synthesis system built around an agitated reaction vessel rather than small laboratory vessels. It automates the coupling, deprotection and wash cycles at batch volumes configured to the customer’s product, with the metering, cleaning and documentation scope agreed for the project.

What reactor sizes are available?

Reactor volume is configured to the peptide, batch size and facility, starting from a pilot-scale trial plan. Mechotech’s verified catalogue sources do not state a fixed volume range, so the volume is confirmed with the client for each project, and the metering, flow measurement, CIP and temperature control are scaled to it.

What compliance and documentation support is available?

The standard compliance scope for the synthesiser is GMP hygienic design with full documentation for qualification. Compliance with any specific standard, such as data-integrity (audit-trail) requirements or a hazardous-area certification, is not assumed: it is specified and confirmed with the client for each project.

Can it be used in a hazardous area?

EX-proof construction can be specified for environments with flammable solvents, or a standard build where area classification allows. The hazardous-area rating and certification are specified and confirmed per project and facility classification.

Does it include cleavage of the peptide from the resin?

An optional cleavage module can release the peptide from the resin and remove side-chain protecting groups, delivering crude peptide ready for downstream purification such as preparative HPLC or industrial preparative HPLC.

How is the vessel cleaned between batches?

Where a clean-in-place (CIP) system is specified, it cleans the reaction vessel and internals between batches, which reduces manual intervention and helps prevent carry-over between products. Cleaning-validation requirements are defined with the client.

Which SPPS chemistry does the synthesiser use?

Solid-phase peptide synthesis is carried out with either Fmoc or t-Boc protecting-group chemistry. The strategy is selected for the peptide and confirmed with the client during project definition.

How does this industrial synthesiser differ from the laboratory peptide synthesiser?

This page covers the industrial version, which is configured to production batch volumes. The Peptide Synthesiser (Automated SPPS) page covers the laboratory-scale, multi-channel system for research use. Choose by batch size and use.

What equipment follows the peptide synthesiser?

Mechotech’s peptide line continues with preparative and industrial HPLC, concentration, lyophilisation and solvent recovery, including Industrial Preparative HPLC, the Rotary Evaporator, the Freeze Dryer / Lyophiliser and the Acetonitrile Recovery System. The hub is Peptide & Purification Solutions.

Does Mechotech supply it turnkey?

Mechotech supplies the industrial peptide synthesiser as an engineered system configured to the customer’s peptide and facility, covering design, manufacture, installation and commissioning. The reactor, fluidics, CIP, controls, hazardous-area construction and optional cleavage module are confirmed during project definition.

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Industrial Peptide Synthesiser