Peptide & Purification Solutions
Peptide & Purification Solutions
Mechotech delivers a complete, turnkey peptide synthesis and purification line — from solid-phase peptide synthesis through preparative chromatography, concentration, lyophilization and solvent recovery. The range covers laboratory-scale automated synthesizers, GMP industrial single-channel synthesizers, preparative and simulated-moving-bed (SMB) HPLC, dynamic axial compression columns and chromatography media, industrial rotary evaporators, freeze dryers and acetonitrile recovery systems. Each stage is engineered to work together, so a peptide, API or high-value natural-product molecule can be taken from synthesis to purified, dried final product on matched Mechotech equipment.
Manufacturing Process
Peptide Synthesis
Solid-phase peptide synthesis (SPPS) assembles the sequence — laboratory automated synthesizers for research, or industrial single-channel reactors (10 L–5000 L) with a cleavage unit for GMP manufacturing.
Crude Recovery
The crude peptide is cleaved from the resin and recovered, ready for downstream purification.
Preparative Purification
Preparative and semi-preparative HPLC — or continuous dual-column / SMB chromatography for difficult separations — refines the target to high purity with high recovery.
Columns & Media
Dynamic axial compression columns packed with the right stationary-phase media (RPC, IEX, HIC, Affinity, Protein A, Chiral) deliver the required resolution at scale.
Concentration
Industrial rotary evaporators remove organic solvent and concentrate the purified fraction under vacuum at low temperature.
Lyophilization
Freeze drying / lyophilization converts the concentrate into a stable, high-quality peptide powder.
Solvent Recovery
A closed-loop acetonitrile / solvent recovery system reclaims spent mobile phase to high-purity grade for reuse, cutting solvent cost and waste.
Applications
- Therapeutic and GLP-1 class peptide manufacturing
- Peptide API and generic peptide production
- Research and custom peptide synthesis
- Natural-product monomer and isolate purification
- Chiral and difficult isomer separations (SMB)
- Nutraceutical and cosmetic peptide actives
- Analytical-to-commercial scale-up
- GMP downstream purification and solvent recovery
Key Features
Complete Turnkey Line
Synthesis, purification, concentration, drying and solvent recovery from one manufacturer — engineered to integrate as a single workflow.
Lab to GMP Scale
Automated laboratory synthesizers through to industrial reactors and DAC columns, scaling from R&D to multi-kilogram commercial production.
EX-Proof & Compliant
EX-proof (EXD IIB T4 / IP65) and non-EX-proof options with FDA 21 CFR Part 11-compliant automation, audit trail and electronic signatures.
Continuous SMB Purification
Dual-column cyclic and simulated-moving-bed chromatography for high-productivity, low-solvent separation of difficult, high-value molecules.
Closed-Loop Solvent Economy
Integrated acetonitrile / solvent recovery reclaims mobile phase to reusable purity, cutting operating cost and environmental impact.
Single-Source Engineering
Mechotech handles design, manufacture, installation, commissioning and support across the whole peptide line as one accountable partner.
Showing 10 products
Peptide Synthesizer (Automated SPPS)
Mechotech designs and manufactures automated solid-phase peptide synthesizers (SPPS) that build peptide chains one residue at a time on an insoluble resin support, automating the repetitive coupling, deprotection and wash cycles that define peptide chemistry. The system anchors the first amino acid to the resin and then adds each subsequent residue under programmed control, so the operator defines the sequence and the instrument executes it reproducibly from end to end. A multi-channel architecture runs several reaction vessels in parallel and asynchronously, letting a laboratory synthesize a panel of different sequences in a single unattended run. Built for research, biochemistry and molecular-biology laboratories, the platform supports both t-Boc and Fmoc strategies and handles complex, long and chemically modified sequences with consistent, high-fidelity results.
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Industrial Peptide Synthesizer (GMP SPPS)
Mechotech designs and manufactures industrial single-channel solid-phase peptide synthesizers built for GMP peptide manufacturing at production scale. The system centres on a jacketed reaction tank — configurable from 10 L to 5000 L — in which the resin-bound peptide is assembled through precisely controlled, automated coupling, deprotection and wash cycles. Precise liquid dispensing, inert-gas pressure feed of reagents, jacketed temperature control and online flow metering on each solvent line give the repeatable, well-documented process that regulated peptide production demands. Available in EX-proof (EXD IIB T4 / IP65) or standard non-EX construction with local and remote control, the platform scales classical SPPS chemistry from clinical batches through to commercial active-pharmaceutical-ingredient manufacture.
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Preparative & Semi-Preparative HPLC System
Mechotech designs and manufactures turnkey preparative and semi-preparative HPLC systems that separate and purify target compounds — peptides, active pharmaceutical ingredients, and natural-product monomers — from complex reaction mixtures to high purity. Where analytical HPLC only measures a sample, a preparative system is built to recover it: high-pressure infusion pumps drive milligram-to-multi-gram loads through a packed column, a UV or dual-wavelength detector tracks each eluting band, and an automatic fraction collector captures the purified peaks. The result is an isolated, high-purity product ready for further processing, characterisation or formulation. Mechotech engineers the complete system — pumps, injection valve, column, detector, fraction collector and chromatography workstation — for universities, pharmaceutical R&D laboratories and small-scale production.
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Industrial Preparative HPLC (DAC) System
Mechotech designs and manufactures turnkey industrial preparative HPLC systems built on dynamic axial compression (DAC) columns for kilogram-scale purification of active pharmaceutical ingredients and peptides. A DAC column uses a hydraulic piston to keep the packed bed compressed at all times, so the stationary phase stays homogeneous and stable under high flow — the key to reproducible, scalable separations at production volume. Because these processes run large volumes of flammable organic solvents, Mechotech builds the system to EX-proof standards throughout, with fully automated valve control, forward/back/bypass wash modes, high-pressure safety valves and 21 CFR Part 11 compliant software. It is engineered as a complete process skid — DAC column, multi-solvent inlet, high-pressure pumps, detection, automatic fraction collection, slurry tank and auxiliaries — for commercial pharmaceutical, peptide and fine-chemical manufacturing.
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Dual-Column SMB Continuous Chromatography
Mechotech designs and manufactures turnkey dual-column cyclic and Simulated Moving Bed (SMB) continuous chromatography systems for difficult, high-value separations that batch prep chromatography struggles to make economical. By switching mobile-phase inlet and outlet ports along a set of columns in a repeating cycle, an SMB system creates a simulated counter-current movement between the stationary and mobile phases — so feed is introduced continuously and the two product streams are drawn off continuously. This counter-current action sharply lowers solvent consumption and boosts productivity and recovery compared with single-pass batch preparation, which is why it is chosen for isomer splits, chiral separations, and the purification of high-value actives. Mechotech engineers the complete system — columns, precision valves, pumps, detection and software — for pharmaceutical, nutraceutical and fine-chemical manufacturers.
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Preparative Chromatography Columns & Packing Systems
Mechotech designs and manufactures preparative chromatography columns and the electrically-driven packing systems that fill them, engineered for peptide, protein, API and natural-product purification. Built around a recyclable, spring-loaded dynamic-axial-compression (DAC) design, each column holds the packed bed under constant, uniform pressure so it stays stable, homogeneous and efficient wash after wash. Available in internal diameters from 25 to 200 mm with adjustable bed lengths of roughly 5 to 40 cm, the columns are compatible with silica and polymeric media across every common separation mode. The matched packing station compresses the bed electrically — with no compressed gas — for a safe, repeatable, high-density pack every time.
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Chromatography Stationary Phase & Media
Mechotech supplies a complete range of chromatography stationary phases — the silica and polymeric media that do the actual separating inside a purification column. Every grade is built from perfectly spherical, monodisperse particles with a tightly controlled pore size, so packed beds are uniform, mechanically stable and highly reproducible from lot to lot. Particle sizes of 3, 5, 7, 10, 20 and 50 µm span high-resolution analytical-prep work through robust, high-throughput process purification. The portfolio covers normal-phase, reverse-phase (RPC), ion-exchange (IEX), hydrophobic-interaction (HIC), affinity, Protein A and chiral chemistries for peptide, protein, API and natural-product purification.
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Industrial Rotary Evaporator
Mechotech manufactures industrial, large-capacity rotary evaporators for gentle solvent removal and concentration in peptide, pharmaceutical and natural-product processing. A rotating evaporation flask spreads the liquid into a thin, constantly renewed film over a heated bath, so solvent evaporates quickly at a mild temperature under vacuum and is recovered by an efficient condenser. Wetted parts are built in borosilicate glass and PTFE to stand up to aggressive and corrosive solvents, and evaporation flasks are offered in 50 L and 100 L sizes for pilot and production duty. Units run under vacuum or at atmospheric pressure and can be supplied EX-proof and in GMP or non-GMP configurations.
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Freeze Dryer / Lyophilizer
Mechotech designs and manufactures turnkey Freeze Dryer / Lyophilizer systems as part of our process equipment range. We supply the complete machinery — engineering, fabrication, installation, and commissioning — for pharmaceutical, nutraceutical, food, and botanical extraction industries.
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Acetonitrile Recovery System
Mechotech designs and manufactures acetonitrile recovery systems that reclaim spent acetonitrile — and other process solvents — from peptide and pharmaceutical purification streams, returning them to high-purity, reusable grade. In preparative HPLC and peptide purification the mobile phase consumes large volumes of acetonitrile, and the used solvent is otherwise an expensive waste stream; a Mechotech recovery system distils and dehydrates that spent acetonitrile back to a low-UV-absorbance quality suitable for reuse in the same demanding applications. Engineered as an energy-efficient, closed-loop plant with capacities from 300 L/day to 10000 L/day, it distils the collected mobile phase, removes water and impurities, and delivers recovered solvent that meets tight UV-transmittance targets. The result is a substantial cut in raw-solvent purchasing, disposal cost and environmental footprint across peptide, generic-API and fine-chemical manufacturing.
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